Dynamic regulation of IP3 receptor clustering and activity by IP3
نویسندگان
چکیده
منابع مشابه
Regulation of IP3 receptors by cyclic AMP
Ca2+ and cAMP are ubiquitous intracellular messengers and interactions between them are commonplace. Here the effects of cAMP on inositol 1,4,5-trisphosphate receptors (IP3Rs) are briefly reviewed. All three subtypes of IP3R are phosphorylated by cAMP-dependent protein kinase (PKA). This potentiates IP3-evoked Ca2+ release through IP3R1 and IP3R2, but probably has little effect on IP3R3. In add...
متن کاملCooperative activation of IP3 receptors by sequential binding of IP3 and Ca2+ safeguards against spontaneous activity
BACKGROUND Ca2+ waves allow effective delivery of intracellular Ca2+ signals to cytosolic targets. Propagation of these regenerative Ca2+ signals probably results from the activation of intracellular Ca2+ channels by the increase in cytosolic [Ca2+] that follows the opening of these channels. Such positive feedback is potentially explosive. Mechanisms that limit the spontaneous opening of intra...
متن کاملStimulation of Inositol 1,4,5-Trisphosphate (IP3) Receptor Subtypes by Analogues of IP3
Most animal cells express mixtures of the three subtypes of inositol 1,4,5-trisphosphate receptor (IP(3)R) encoded by vertebrate genomes. Activation of each subtype by different agonists has not hitherto been examined in cells expressing defined homogenous populations of IP(3)R. Here we measure Ca(2+) release evoked by synthetic analogues of IP(3) using a Ca(2+) indicator within the lumen of th...
متن کاملIP3 receptors
What are they? Members of a family of intracellular ligand-gated ion channels that allow Ca2+ release from intracellular stores. The endoplasmic reticulum (ER), or specialised regions of it, contains ATP-driven Ca2+ pumps which generate a high Ca2+ concentration in the ER lumen. When inositol 1,4,5-trisphosphate (IP3) binds to IP3 receptors, the channel region of the receptor opens, allowing Ca...
متن کاملA General Analysis of Single IP3 Receptors Modulated by Cytosolic Ca2+ and IP3
In this report, we remove the constraint of detailed balance and give a general discussion of the modulation of cytosolic Ca2+ and IP3 on the IP3R channel. By introducing the circulation decomposition theorem in stochastic process, the gating mechanism of single IP3R is neatly analyzed. Some remarkable differences are found to distinguish between equilibrium and non-equilibrium dynamics. Eviden...
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ژورنال
عنوان ژورنال: Channels
سال: 2009
ISSN: 1933-6950,1933-6969
DOI: 10.4161/chan.3.4.9247